DEFINE

Determining the Effectiveness of a FeNO-guided asthma management INtervEntion in primary care (DEFINE) is a research study conducted by the University of Oxford. Its aim is to help health care professionals in GP surgeries provide a more personalised approach to managing patients’ asthma by using FeNO to guide decisions about their treatment.
FeNO stands for fractional exhaled nitric oxide and is measured using a simple breath test.

Nitric oxide is a gas which everyone breathes out. People with inflamed airways breathe out more nitric oxide than people whose airways are not inflamed. These patients are more likely to have an asthma attack if their inflammation remains untreated.
FeNO is already measured in patients with severe asthma who are seen in hospital clinics. However, very few GP surgeries routinely use FeNO to help them monitor treatment.

A copy of the Research Information Sheet can be found below:

Participant Information Leaflet for patients aged 16 years and older

Participant Information Leaflet for parents/guardians of patients aged 12 to 15 years